David Lacoste
NON-EQUILIBRIUM FLUCTUATIONS AND MECHANOCHEMICAL COUPLINGS
OF A MOLECULAR MOTOR
We investigate theoretically the violations of Einstein and Onsager
relations, and the efficiency for a single processive motor operating
far from equilibrium using an extension of the two-state model
introduced by Kafri et al.
[Biophys.
J. 86, 3373 (2004)]. With
the aid of the Fluctuation Theorem, we analyze the general features of
these violations and this efficiency and link them to mechanochemical
couplings of motors. In particular, an analysis of the experimental
data of kinesin using our framework leads to interesting predictions
that may serve as a guide for future experiments.
Ref.: D. Lacoste, A. Lau and K. Mallick, cond-mat/0707.4344, Phys.
Rev. Lett. (2007).